almost significantlyp = 0.05239
Probability of OS was almost significantly higher in period V compared with period IV (1.0 vs. 0.74, p = 0.05239), and no significant differences were found in the probability of EFS and RFS between periods IV and V (0.61 ± 0.07 vs. 0.71 ± 0.1 and 0.67 ± 0.08 vs. 0.71 ± 0.12; Figure S6 ).