Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α <sup>3.7I</sup> form of α-thalassaemia using genome-wide microarray data.

Wellcome Open Res · 2020 · PMC8474104 · PMID 34632085

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highly significantno p-value reported

While a number of signals were highly significant, the directions of effect were inconsistent and were often opposite to those derived from direct genotypes (i.e indicating a risk effect rather than protective effect).

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Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α &lt;sup&gt;3.7I&lt;/sup&gt; form of α-thalassaemia using genome-wide microarray data.

The sentences

Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α <sup>3.7I</sup> form of α-thalassaemia using genome-wide microarray data.