Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance.

The mitochondrial complex I subunit NDUFA6 , which was significantly reduced in both aged human and rat hearts in microarray analysis, demonstrated a highly significant inverse correlation ( R 2 =0.4059; P =0.008) in expression with advancing age (Figure 3A ).

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