NMR studies of group 8 metallodrugs: ¹⁸⁷Os-enriched organo-osmium half-sandwich anticancer complex.

The IC 50 follows an expected trend of activity for change in the monodentate ligand: I > Br > Cl, whereby the iodido complex is the most active and the chlorido complex is the least, due to weakening of the Os–X bond decreasing stability, and hence greater drug deactivation before reaching the target sites (Table S2 † ).

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