Effect of Amplitude Spectral Area on Termination of Fibrillation and Outcomes in Pediatric Cardiac Arrest.

23 , 24 , 34 We did, however, find a trend towards significance between AMSA‐avg and ROSC in pediatric patients, which is similar to adult OHCA trials. 33 , 34 , 35 , 36 Additionally, we found no association between AMSA‐avg and 24‐hour survival or survival to hospital discharge, which is in contrast to findings from adult OHCA VF studies. 33 , 34 , 35 , 36 AMSA has been shown to predict successful defibrillation in animals and multiple adult OHCA studies, 24 , 30 , 34 , 35 , 36 , 37 , 38 with AMSA values significantly greater in successful defibrillation (defined as restoration of a perfusing rhythm) compared with unsuccessful defibrillation.

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47 With respect to secondary outcomes, we did find a trend toward significance between AMSA‐avg and ROSC, which is similar to an adult witnessed OHCA VF study in which AMSA‐avg was associated with pre‐hospital ROSC, hospital admission, and hospital discharge. 33 A follow‐up to that study by Indik and colleagues evaluated adult VF OHCA and also found that AMSA‐avg was highly associated not only with survival to hospital discharge, but also survival with good neurologic outcome. 37 Additionally, these authors were able to demonstrate that AMSA‐avg could predict resuscitation outcome independent of chest compression quality.

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