Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants.

In either case, this may be significant as the 5’UTR contains many important regulatory elements that impact replication and translation as well as recombination events that generate the viral sgmRNAs ( Li et al., 2008 ; Zuniga et al., 2004 ) and therefore may impact viral fitness.

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