Catecholamine Surges Cause Cardiomyocyte Necroptosis <i>via</i> a RIPK1-RIPK3-Dependent Pathway in Mice.

These are highly significant discoveries because they not only provide a new mechanistic link between many common and rare forms of heart disease and cardiomyocyte necrosis but also identify RIPK1 and RIPK3 as potentially new therapeutic targets for protecting the heart against injury by catecholamine surges or excessive β-adrenergic stimulation.

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