Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB<sub>1</sub> Receptor Antagonism.

Front Pharmacol · 2021 · PMC8481666 · PMID 34603022

Europe PMC DOI

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highly significantp = 0.023actually significant

Mitragynine Impairs Place Learning and Reversal Learning in the IntelliCage In the 5-day learning phase, two-way repeated measures ANOVA yielded highly significant treatment-by-day place learning in the IntelliCage system ( Figure 4A ; effect of treatment: F 5, 54 = 5.571, p = 0.023; effect of day: F 4, 216 = 8.854, p = 0.005; treatment × day interaction: F 20, 216 = 2.659, p = 0.014).

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