highly significantp < 0.0001
At the end of 12 weeks, in group A, the total reduction of comedones was 37% (p < 0.0001, highly significant), that of papules was 94.7% (p < 0.0001, highly significant), that of pustules was 100% (p < 0.0001, highly significant), and that of the ASI was 52.5% (p< 0.0001, highly significant; Figure 1 ).