Moreover, long-term follow-up results from the EORTC 18991 trial revealed a diminished impact of adjuvant pegylated IFN-α 2b as compared with the benefit seen in the initial trial results and showed only a marginally significant impact on RFS, whereas no increase in OS or distant metastasis-free survival has been observed [ 27 ].
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The Status of Adjuvant and Neoadjuvant Melanoma Therapy, New Developments and Upcoming Challenges.
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