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Factors associated with the use of complementary therapies in Taiwanese patients with systemic lupus erythematosus: a cross-sectional study.

BMC Complement Med Ther · 2021 · PMC8485480 · PMID 34598699

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an increasing trendno p-value reported
A systematic review of epidemiological studies have indicated an increasing trend of SLE prevalence over time, with the highest estimates of prevalence in North America, at 241 per 100,000 people [ 3 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.