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Mucoprotective drugs can prevent and treat nonsteroidal anti-inflammatory drug-induced small bowel enteropathy: a systematic review and meta-analysis of randomized controlled trials.

Ther Adv Gastroenterol · 2021 · PMC8488515 · PMID 34616487

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an increasing trendno p-value reported
While the incidence of upper gastrointestinal (GI) events decrease, an increasing trend in lower GI events was observed among these patients. 3 Manifestations of SBE are nonspecific, with various signs and symptoms, including abdominal discomfort, diarrhoea and constipation, and consequences like iron-deficiency anaemia or protein loss.

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