Analysis of Metabolite and Lipid Association Networks Reveals Molecular Mechanisms Associated with 3-Month Mortality and Poor Functional Outcomes in Patients with Acute Ischemic Stroke after Thrombolytic Treatment with Recombinant Tissue Plasminogen Activator.

50 We observed a reduction of 3-hydroxybutyrate concentration ( P -value = 3 × 10 –5 and FDR = 0.0043) in patients with the PFO; there are also a decreasing trend for glucose ( P -value = 0.0101 and FDR = 0.0683) and an increase of acetone ( P -value = 0.0007 and FDR = 0.0129) which are, however, not significant after adjustment.

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