Identifying causal variants by fine mapping across multiple studies.

To generate loci for fine mapping, we centered 1 megabase windows around genome wide-significant peak SNPs (p-value ≤ 5 * 10 −8 ), discarding all SNPs that did not reach even marginal significance ( p > 0.05), as they were highly unlikely to be informative and would slow down analyses.

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If one population has an obvious GWAS signal while the other population(s) lack even a marginally significant signal in the same locus, applying CAVIAR to the population with signal may be more appropriate.

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