SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer.

JCI Insight · 2021 · PMC8492341 · PMID 34549724

Europe PMC DOI

hedged sentences

0.0758

closest p · 1.5× alpha

0.0758

boldest claim

The sentences

borderline significantP = 0.0758so close (0.05 < p ≤ 0.1)

A borderline significant association with shorter PFI was observed for stage IVa versus IIIc cancer (HR = 3.19, 95% CI = 0.89–11.46, P = 0.0758), whereas an opposite trend was found for higher total CD8 + TIL count (HR = 0.67, 95% CI = 0.41–1.09, P = 0.1040) and SLFN11 H-score assessed in cancer cells only (HR = 0.62, 95% CI = 0.38–1.02, P = 0.0620).

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extremely significantno p-value reported

All the aforementioned signatures showed extremely significant positive correlations with SLFN11 expression, with close reproducibility among signatures of similar meaning generated by different authors (see Figure 5B ).

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