Effect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial.

J Nephrol · 2021 · PMC8494695 · PMID 33382448

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

of borderline significanceno p-value reported

showed that 0.5 mEq/kg sodium bicarbonate supplementation for 30 days did reduce plasma aldosterone and endothelin-1 levels in patients with CKD stage G1 or G2.[ 12 ] In agreement, we also observed that sodium bicarbonate reduced plasma aldosterone, although this was of borderline significance.

also in 2,624 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.