Serum secreted frizzled-related protein 5 in relation to insulin sensitivity and its regulation by insulin and free fatty acids.

Interestingly, we also observed strong positive correlations of serum SFRP5 with circulating concentrations of adiponectin ( r = 0.55, p < 0.001) and this association remained highly significant in multiple regression analysis ( β = 0.50, p < 0.0001), whereas association between SFRP5 and insulin sensitivity was no longer significant after adjusting for serum adiponectin.

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