Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.

However, both the nuo-6 mutant and the constitutively active ATFS-1 mutants had a 2.5- to 19.5-fold increase in hsp-16.2 levels, which failed to reach significance due to variability between replicates, and the fact that hsp-16.2 expression levels can be increased up to 60-fold.

also in 4,113 other papers

Similarly, there was a highly significant overlap of up-regulated genes between atfs-1(et15) mutants and each of the other stress response pathways . atfs-1(et15) had a 25% overlap with genes of the ER-UPR pathway ( Fig 2B ); 22% overlap with genes of the Cyto-UPR pathway ( Fig 2C ); 26% overlap with genes of the DAF-16–mediated stress res

also in 132,142 other papers