The Ganglioside Monosialotetrahexosylganglioside Protects Auditory Hair Cells Against Neomycin-Induced Cytotoxicity Through Mitochondrial Antioxidation: An <i>in vitro</i> Study.

Moreover, our results also showed that exposure of cochlear explant cultures to GM1 protected HC cells in the middle and basal turns of the cochlea from damage; since the damage caused by aminoglycoside drugs shows a decreasing trend from the basal turn to the apical turn of the cochlea ( Zhang et al., 2019 ) and high-frequency hearing loss is the first and most severe impairment in patients with ototoxic hearing loss ( Guo et al., 2019 ), the protective effect of GM1 on high-frequency hearing may have potential clinical significance.

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