Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study.

Finally, because of the limited ancestral diversity in the contributing studies, the analysis was limited to patients of European ancestry, limiting the generalizability of the findings to other populations, and reducing the power to identify effects of variants that are rare in European ancestry populations such as the ADH1B variant discussed above, or the ALDH2 Glu504Lys polymorphism (rs671) that shows extraordinarily significant association to AUD, but only in populations where the locus is actually polymorphic.

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However, the top PTPRD SNP association that almost reached significance in the meta-analysis of naltrexone-treated patients in COMBINE and PREDICT, was driven by a genome-wide significant association in the COMBINE sample, while showing no significant association in the PREDICT sample, although the direction of effect in PREDICT was consistent with the effect in COMBINE and the 95% confidence intervals overlapped (Supplementary Fig.

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