Barely Significant
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The Effects of Prophylactic Dexmedetomidine Administration on General Anesthesia Recovery Quality in Healthy Dogs Anesthetized With Sevoflurane and a Fentanyl Constant Rate Infusion Undergoing Elective Orthopedic Procedures.

Front Vet Sci · 2021 · PMC8505894 · PMID 34651033

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may be significantno p-value reported
These cardiovascular effects may be significant (i.e. reductions in cardiac output); however, they are sometimes observed to a lesser extent with slow administration at a low dose in dogs ( 27 , 28 ).

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