Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids.

BMC Biotechnol · 2021 · PMC8507123 · PMID 34641840

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an overall trendno p-value reported

This was particularly apparently at day 40 where round microwells showed an overall trend of downregulation, C microwells showed similar numbers of up and downregulated genes, and butterfly and peanut microwells were associated with upregulation of transcripts (Figs. 4 a) (Additional file 1 : Fig.

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a notable trendno p-value reported

While some cortical markers ( NEUROD2 , NEUROD6 ) showed significant upregulation at day 40 in all shapes, a notable trend for cortical development was not observed across different shapes and time points.

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