Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis.

At 11 months post-DEN injection, LmiR21KO tend to have a higher liver weight than their control littermates (miR21fx—CTRL), while miR21KO mice display highly significant hepatomegaly ( Figure 2 A).

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Despite a high variability between mice, inherent to these analytical methods, a positive trend for ERK1, p38, and JNK over-activation was observed in DEN-treated LmiR21KO or miR21KO mice as compared to CTRL mice ( Figure 4 C).

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