Cholecystokinin Receptor Antagonist Improves Efficacy of Chemotherapy in Murine Models of Pancreatic Cancer by Altering the Tumor Microenvironment.

Similarly, β-catenin protein expression was also decreased in tumors of mice treated with the combination therapy ( Figure 4 I,J); however, this difference did not quite reach significance. β-catenin is involved in cell–cell adhesion through interaction with the E-cadherin cell-adhesion complex [ 44 ], and gastrin has been shown to increase metastases by inducing β-catenin nuclear translocation [ 45 ].

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