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The impact of guidance on the supply of codeine-containing products on their use in intentional drug overdose.

Eur J Public Health · 2021 · PMC8514187 · PMID 34041521

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an increasing trendno p-value reported
30 In Australia, similar up-scheduling of codeine compound analgesics in 2010 did not impact on an increasing trend in codeine-related poison centre calls, while more recent legislation moving codeine-related medication to prescription only resulted in fewer calls recorded. 31 , 32 We sought to investigate if the guidance introduced in Ireland in 2010 impacted on the rate of codeine-related IDOs, using national surveillance data on hospital-presenting self-harm.

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a decreasing trendno p-value reported
In the second half of the study period, between October 2010 and December 2013, a decreasing trend in the rate of codeine-related IDOs was detected (QPC: −2.0%, −3.1 to −0.8).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.