Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs.

Structurally, A789V may be significant due to its position near the catalytic motif C as well as the residue D700 in the motif A, however the overall protein structure suggests that all the mutations together may play a role in modifying the active site and facilitating nucleoside discrimination [160] , [161] .

also in 13,097 other papers