Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths.

We found that all auto-Abs, except those neutralizing only IFN-ω at a concentration of 10 ng/mL, were highly significant risk factors in comparisons of patients with critical or severe COVID-19 with controls ( Table 1 and Table S2).

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