A positive trend in the increase in these inflammatory biomarkers in the smokers compared with never smokers was reported. 22 This reflects on the hypothesis that smoking significantly impacts circulating inflammatory biomarkers, which could be a contributing factor in developing MPNs. 22 Two similar studies 15 , 20 investigated the prevalence and frequency of the clonal hematopoiesis (JAK2V617F mutation) in smokers compared to non-smokers.
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Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.
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