A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway.

Autophagy · 2021 · PMC8526018 · PMID 33249983

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highly significantno p-value reported

A DisGeNET analysis of the RNA-seq derived from Zfp418 knockdown in NRVMs revealed a highly significant enrichment of our gene set in Alzheimer disease and heart failure, including Dapk2 in both (Table S9), supporting the role of ZNF418 in protein degradation.

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