The Association Between <i>PNPLA2</i> Methylation in Peripheral Blood and Early-Stage Lung Cancer in a Case-Control Study.

The methylation of PNPLA2_CpG_9 showed a borderline significant association with LC in males (OR =0.75, 95% CI: 0.56–1.00, P = 0.052), but not in females ( Table 4 ).

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1 Data from the Global Burden of Disease study demonstrated that, from 1990 to 2017, the age-standardized death rates for LC showed a decreasing trend in men and an increasing trend in women worldwide, while raised in both men and women in China, indicating that LC in China represents a tremendous burden on the global epidemic. 2 For non-small cell lung cancer (NSCLC) patients, a decline in the 5-year survival rates with the clinical stages was well documented, ranging from 92% at the stage IA1 to 6% at the stage IV. 3 Therefore, other than the development of treatment and therapy for LC, early detection may be an alternative option for the easing of LC burden in China.

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