In a dose-response analysis using the individual-level data, an overall trend for a progressive reduction in risk of ankylosing spondylitis was observed when given a stepwise increase in the number of inherited exposure alleles ( P value for trend = 0.020) or in the value of the HMGCR score ( P value for trend = 0.046) ( Figure 2 ).
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HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis.
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