Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.

Both the pro and active forms were present in wild-type mouse brain, but there was a highly significant conversion from the inactive to the active form in 5M P301S mice ( P < 0.001, one-way ANOVA) ( Fig. 6, A and B ).

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