FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.

Conversely, infection with Foxo1 AdV significantly reduced hepatocyte Fgf21 expression, whereas shFoxo1 AdV infection significantly increased Fgf21 mRNA ( Figure 3G ); as both viruses dose-dependently affected Fgf21, the expected linear trend in Fgf21 expression was also highly significant (p < 0.0001).

also in 132,142 other papers