Barely Significant
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PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.

J Mol Cell Biol · 2021 · PMC8530519 · PMID 34048566

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a decreasing trendno p-value reported
an increasing trendno p-value reported
Although NRF2 knockdown only showed an increasing trend in intracellular TG accumulation and gene levels of SREBP-1c and PPARγ, as well as a decreasing trend of PGC1α compared with the control group, the differences in the effects induced by PSA overexpression with and without NRF2 knockdown were statistically significant, indicating that the effect of PSA on lipid metabolism was at least partly due to the NRF2 signaling pathway.

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