highly significantp < 10 −6
This is a highly significant enrichment relative to the <3% of background genes with known interactions (Fisher’s test p < 10 −6 ), confirming that our analytical pipeline is an effective approach to enrich for druggable targets. 645 (34%) of the compounds are predicted in a single patient, ranging from 15 in patient 17 to 205 in patient 18, further highlighting the importance of a patient-specific approach (Fig.