In addition to CD8 + CD28 null T-cells, two studies have shown that COPD patients have significantly higher numbers of CD4 + CD28 null populations in the lungs or blood [ 44 , 45 ], whereas another study found only a slight trend of increase in these cells [ 40 ].
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Accumulation of CD28<sup>null</sup> Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients.
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