Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis.

In CA-CRC, the hypermethylation frequencies of NTSR1 , SOCS2, and SOCS1 (32–42%) clearly exceeded those of the paired normal tissues (0%); however, statistical significances were lost when the Bonferroni correction was applied ( Figure 4 a), and only NTSR1 remained borderline significant ( p = 0.057).

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