It not only affects the end stages of renal insufficiency, but also reflects the entire course of the disease: a meta-analysis of 41 studies with 2700 test subjects revealed a highly significant correlation between plasma HCys and the reciprocal value of the glomerular filtration rate [ 48 ].
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Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline-A Review.
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