Sub-Cellular Metabolomics Contributes Mitochondria-Specific Metabolic Insights to a Mouse Model of Leigh Syndrome.

Although this assures the few metabolites reported are indeed of significant value, many possibly significant alterations may be lost.

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In line with power calculations performed (G* Power 3; Universität Dusseldorf) at the inception of this study, a t-statistic with a p -value of <0.1 was considered statistically significant, while effect sizes (Cohen’s D value; D) of ≥1.0 were considered practically significant and used complimentary to the t -test [ 48 ].

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Notably, three compounds approached the cut-off for significance in the whole-brain samples ( p < 0.15; D > 0.8), while none but the reported quadriceps-derived metabolites showed borderline significant differences in means.

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