Macrophage Depletion via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo.

Viruses · 2021 · PMC8538323 · PMID 34696433

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

a possible trendno p-value reported

Contrary to previous reports utilizing adenoviral vectors, clodronate liposome pretreatment resulted in a significant decrease in transgene expression in heart and liver tissue ( p < 0.05), and a possible trend towards a decrease in the spleen. 2.

also in 1,410 other papers

highly significantno p-value reported

These results underscore the highly significant role that the immune system plays in influencing the distribution and relative numbers of transduced cells in the context of AAV-mediated gene delivery.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.