Direct and Base Excision Repair-Mediated Regulation of a GC-Rich <i>cis</i>-Element in Response to 5-Formylcytosine and 5-Carboxycytosine.

The repression of the promoter activity caused by 5-fC between 6 and 24 h post-transfection was statistically highly significant ( p = 8.6 × 10 −6 , Student’s two tailed heteroscedastic t-test), whereas the effect of 2′-( R )-fluorinated 5-fC was not ( p = 0.62).

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