an increasing trendp -value = 0.374
While the proportion of patients with a MetHbia rate greater or equal to 5% was stable over the study period, the proportion of patients with a MetHbia rate of 25% or more seemed to have an increasing trend after the legalization of this product from 4.76% to 8.63% (PR = 1.81, 95% CI = [0.68–6.82], p -value = 0.374).