Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes <i>via</i> Upregulation of NFκB Pathway.

p50 protein expression was significantly increased in DN and a slightly increasing trend was found in the case of SC adipocytes ( Figure 5C ).

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Protein expression of IκBα, the inhibitor of NFκB transcription factor, decreased significantly upon irisin treatment in SC and a decreasing trend was observed in DN adipocytes ( Figure 5D ), indicating the upregulation of NFκB pathway.

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RT-qPCR validation indicated significant upregulation of NFKB1 (p50 subunit) and RELA (p65 subunit) in DN, while an increasing trend was observed in SC adipocytes ( Figures 5A,B ). p50 protein expression was significantly increased in DN and a slightly increasing trend was found in the case of SC adipocytes ( Figure 5C ).

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