Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study.

Results: Based on our results, for acoustic parameters in the range of therapeutic applications, the maximum shear stress was lower than 4 kPa. Shear stress was approximately independent from shell viscosity whereas it decreased by increasing the shell stiffness. Moreover, shear stress showed an increasing trend with acoustic pressure.

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When the shell viscosity is low, the bubble can be activated more easily. By increasing the shell viscosity from 4 × 10 -9 kg/s to 9 × 10 -9 kg/s , the maximum bubble radius decreases from 1.74 μm to 1.69 μm. A more viscose shell has a substantially more damping effect on bubble oscillation leading to lower oscillation amplitudes. Furthermore, by increasing the shell viscosity, the compression velocity of the bubble wall decreases linearly from 1.05 m/s to 0.85 m/s. A decreasing trend was expected for wall stress by increasing shell viscosity, but wall stress has a negligible increasing trend by increasing the shell viscosity as seen in Figure 7b .

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