Trimodal therapy with high-dose-rate brachytherapy and hypofractionated external beam radiation combined with long-term androgen deprivation for unfavorable-risk prostate cancer.

A decreasing trend in grade 3 and any-grade toxicities was observed after the introduction of IMRT at our institution (2.3 versus 0% and 33.7 versus 22.9%, respectively); longer follow-up is, however, needed to draw any meaningful conclusions.

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