Oral vaccination with recombinant Lactobacillus plantarum encoding Trichinella spiralis inorganic pyrophosphatase elicited a protective immunity in BALB/c mice.

Furthermore, the cytotoxocity of anti-rTsPPase serum (1:100 dilution) at 48 and 72 h after culture was obviously stronger than that of serum from the NC8 and MRS control mice ( F = 200.422, P < 0.05); larval mortality at 24, 48 and 72 h after culture was 19.5%, 43.0% and 76.5%, respectively, the cytotoxicity had an increasing trend following the extension of culture times ( F = 137.839, P < 0.05, r = 0.993) ( Fig 10F ).

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