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Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats.

Exp Ther Med · 2021 · PMC8549097 · PMID 34721693

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a decreasing trendno p-value reported
Compared with those in the control group, LVID-d and LVID-s in the rat hearts demonstrated an increasing trend following 5-FU treatment, whereas LVEF and LVFS demonstrated a decreasing trend.

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an increasing trendno p-value reported
The results indicated that the heart weight and HWI of AM groups demonstrated an increasing trend compared with the control groups, although the increase in heart weight was not significant in the YM group. 5-FU may have induced structural changes, such as hypertrophy and dilatation of the myocardium, and induced more serious myocardial injury in aging rats ( Fig. 2B and C ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.