Compared with those in the control group, LVID-d and LVID-s in the rat hearts demonstrated an increasing trend following 5-FU treatment, whereas LVEF and LVFS demonstrated a decreasing trend.
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Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats.
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The sentences
The results indicated that the heart weight and HWI of AM groups demonstrated an increasing trend compared with the control groups, although the increase in heart weight was not significant in the YM group. 5-FU may have induced structural changes, such as hypertrophy and dilatation of the myocardium, and induced more serious myocardial injury in aging rats ( Fig. 2B and C ).