Apolipoprotein E Genetic Variation and Its Association With Cognitive Function in Rural-Dwelling Older South Africans.

In the first model assessing association with all genotypes for all individuals, marginally significant associations were observed for ε2 homozygotes where executive function scored higher by ~0.5 standard deviations ( p =0.037, SE=0.23), and for ε3/ε4 heterozygotes where visuospatial ability scores were lower ( p =0.046, SE=0.14).

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Our models explained modest variation of cognitive function mostly due to highly significant associations observed with age (cognition score decreasing with increasing age) and level of education (cognition score increasing as higher levels of education are achieved), which are known to influence normal cognitive function.

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