29 ) The presence of both non-phosphorylated (NAD + and NADH) and phosphorylated (NADP + and NADPH) forms may be significant in making it possible for several kinds of redox reactions to co-exist in a cell and/or to control traffic of metabolic pathways. 30 ) NAD kinase is the sole NADP + biosynthetic enzyme and catalyzes the phosphorylation of NAD + to NADP + in the presence of ATP (ATP-NAD kinase: NAD + + ATP → NADP + + ADP) (Fig. 1 A).
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Polyphosphate-dependent nicotinamide adenine dinucleotide (NAD) kinase: A novel missing link in human mitochondria.
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