Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca<sub>V</sub>1.1 gating.

Also, charge neutralization (E216Q) in GFP-Ca V 1.1e resulted in a highly significant, albeit smaller, right shift of voltage dependence of activation compared to wild-type controls (GFP-Ca V 1.1e: 10.0 ± 1.2 mV; GFP-Ca V 1.1e-E216A: 16.8 ± 1.2 mV; p < 0.001) ( Fig. 3 , G–J ).

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